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目的:观察左卡尼丁和川芎嗪对肢体缺血再灌注损伤的保护作用。方法:下肢急性动脉栓塞导管取栓术后患者共114例,随机分为A、B、C三组,分别为常规治疗组、左卡尼丁组和联用左卡尼丁及川芎嗪组。分别于术前、术后3、24、72 h共4个时点(分别简称为T1、T2、T3、T4),检测三组患者肌酸激酶(CK)、乳酸脱氢酶(LDH)和丙二醛(MDA)的变化。结果:三组患者T2时点CK、LDH和MDA比T1时都明显升高(P<0.05)。T3、T4时B、C两组CK与A组比较有显著差异(P<0.05),T4时C组CK下降较B组更为显著(P<0.05)。T4时B、C两组LDH与A组比较有显著差异(P<0.05),T3、T4时C组LDH与A、B组同时点比较都有显著差异(P<0.05)。T4时B、C两组MDA与A组比较有显著差异(P<0.05),C组MDA较B组下降更明显(P<0.05)。结论:左卡尼丁和川芎嗪对肢体缺血再灌注损伤具有一定的保护作用,两者联用效果更理想。
Objective: To observe the protective effect of ligustrazine and ligustrazine on limb ischemia-reperfusion injury. Methods: A total of 114 patients undergoing acute arterial embolization and catheterization of the lower extremities were randomly divided into three groups: A, B and C, which were the conventional treatment group, the levofain group, the levocarnitine group and the ligustrazine group. The levels of creatine kinase (CK), lactate dehydrogenase (LDH), and lactate dehydrogenase (LDH) were measured at 3, 24 and 72 h postoperatively in 4 time points (T1, T2, T3 and T4 respectively) Malondialdehyde (MDA) changes. Results: The CK, LDH and MDA of the three groups at T2 were significantly higher than those at T1 (P <0.05). There were significant differences between CK and group A in T3 and T4 (P <0.05), and CK in group C was more significant than that in group B at T4 (P <0.05). There was a significant difference (P <0.05) between LDH of group B and group C at T4 (P <0.05). There was significant difference between group C and group LD at T3 and T4 (P <0.05). T4 at B, C two groups of MDA and A group were significantly different (P <0.05), C group MDA decreased more significantly than the B group (P <0.05). CONCLUSION: LUCC and ligustrazine have a protective effect on limb ischemia-reperfusion injury, and the synergistic effect is better.