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本文目的在于观察雌性激素是否具有致癌作用以及与γ射线全身照射结合使用是否具有加重致癌作用。 用子宫次全切除的雌性Wistar大鼠,分4组。第1组动物全身γ射线照射300rad,照后1天开始肌肉注射戊酸雌二醇(E)10mg/kg体重和己酸孕酮(P)1250mg/kg体重,以后每2周注射1次,共注射24次;第2组单纯γ射线照射;第3组单纯EP注射;第4组对照。每组动物40～46只。 1～4组动物肿瘤发生率依次为61.5、90.9、30.8和10.3％。前3组肿瘤发生率明显高于对照组(p<0.05或<0. 01)。第1、2组动物肿瘤虽然均主要来自脑垂体和乳腺,但肿瘤类型不同,第2组主要为良性乳腺纤维腺癌,恶性与良性肿瘤之比为0.5:1;而第1组乳腺肿瘤主要为恶性,其比值为5.5:1,此外,脑垂体肿瘤发生率比第2组或第3组的高,依次为46.2、6.1和26.9％。除肿瘤外,在第1、3两组动物有较多子宫积脓,其发生率分别达78.6和81.4％。
The purpose of this paper is to observe whether estrogen has an oncogenic effect and whether it has an aggravating oncogenic effect in combination with systemic irradiation with gamma rays. Sub-total hysterectomy with female Wistar rats, divided into 4 groups. Group 1 animals were exposed to whole body gamma irradiation for 300 rad. One day after irradiation, intramuscular injection of estradiol valerate (E) 10 mg / kg body weight and caproic acid progesterone (P) 1250 mg / kg body weight were injected once every two weeks for a total of Injection 24 times; Group 2 pure gamma irradiation; Group 3 pure EP injection; Group 4 control. Each group of animals 40 ~ 46. The incidences of tumor in 1 ~ 4 groups were 61.5, 90.9, 30.8 and 10.3%. The first three groups of tumor incidence was significantly higher than the control group (p <0.05 or <0.01). The first and second groups of animal tumors are mainly from the pituitary gland and breast, but the tumor types are different, the second group is mainly benign breast fibroadenocarcinoma, the ratio of malignant and benign tumors is 0.5: 1; while the first group of breast tumors are mainly Malignant, the ratio of 5.5: 1, in addition, the incidence of pituitary tumors higher than the group 2 or 3, followed by 46.2,6.1 and 26.9%. In addition to the tumor, in the first and the first two groups of animals have more uterine empyema, the incidence rates were 78.6 and 81.4%.