论文部分内容阅读
溴隐亭对高催乳素血症有良好疗效,但具有难以克服的副反应。Lysuride是一种8-α-麦角灵,在体外和体内均具有强力的多巴胺激动作用。作者评价了Lysuride对高催乳素血症的临床疗效和安全性。 24例女性病人,血清催乳激素浓度为450～4050 mU/L。Lysuride起始剂量为0.1 mg,每晚1次,饭时服用,以后每次增加0.1 mg,逐步递增至日剂量达1.2 mg,或出现难以耐受的副作用,或血清催乳激素降至正常水平(≤360 mU/L)。受试病人实际服用Lysuride 1～40个月(平均5.4个月),日剂量0.1～1.2 mg(平均0.4 mg)。
Bromocriptine has a good effect on hyperprolactinemia, but has unavoidable side effects. Lysuride is an 8-alpha-ergoline that has potent dopamine agonism both in vitro and in vivo. The authors evaluated the clinical efficacy and safety of Lysuride for hyperprolactinemia. 24 cases of female patients, serum prolactin concentration 450 ~ 4050 mU / L. The starting dose of Lysuride is 0.1 mg once daily at night, 0.1 mg at each additional dose, and then gradually increased to a daily dose of 1.2 mg with unpleasant side effects or serum prolactin levels down to normal (≤ 360 mU / L). The patients actually took Lysuride for 1 to 40 months (average 5.4 months) and the daily dose of 0.1 to 1.2 mg (mean 0.4 mg).