1983年初,纽约某医学院有一产妇分娩一个18三体婴儿,她问产科医师是否她妊娠早期血甲胎蛋白(AFP)低值与染色体异常有关。他的问题促使产科医师收集一组母亲孕期血AFP值与各种染色体异 In early 1983, a New York medical school had a mother giving birth to a trisomy 18 and asked the obstetrician if she had low levels of alpha-fetoprotein (AFP) in her first trimester associated with chromosomal abnormalities. His question prompted obstetricians to collect a set of mothers’ AFP values ​​during pregnancy and various chromosomal abnormalities