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目的:了解抗菌药品不良反应/事件(ADR/ADE)发生特点及相关因素,为安全用药提供依据。方法:回顾性分析2011~2013年我院妇产科上报的抗菌药物ADR/ADE报告。结果:165例ADR/ADE患者,平均年龄(28.76±6.80)岁,年龄越高,ADR/ADE发生率越高;青霉素类药物ADR/ADE发生率2.41%,居首位;头孢菌素类药物ADR/ADE例数占73.33%,但ADR/ADE发生率低于均值0.47%;超剂量使用与ADE发生有显著关系,超剂量使用头孢呋辛、头孢曲松发生ADE,P值分别为0.002,0.034;165例ADR/ADE患者,静脉滴注149例,肌内注射12例,口服4例。结论:加强抗菌药物处方审核和护理干预,加强ADR高发生率药物监测,严格控制输液量,以减少或避免ADR/ADE发生。
Objective: To understand the characteristics and related factors of ADR / ADE and provide the basis for safe medication. Methods: The ADR / ADE reports of obstetrics and gynecology reported in our hospital from 2011 to 2013 were retrospectively analyzed. Results: The average age (28.76 ± 6.80) of 165 ADR / ADE patients and the higher the incidence of ADR / ADE were. The incidence of penicillin ADR / ADE was 2.41% ADR / ADE cases accounted for 73.33%, but the incidence of ADR / ADE was lower than the mean 0.47%; overdose use and ADE have a significant relationship, overdose cefuroxime, ceftriaxone ADE occurred, P values were 0.002, 0.034; 165 cases of ADR / ADE patients, intravenous infusion of 149 cases, intramuscular injection of 12 cases, 4 cases of oral administration. Conclusions: To strengthen the prescription review and nursing intervention of antibiotics, strengthen the drug monitoring of high incidence of ADR and strictly control the infusion volume to reduce or avoid the occurrence of ADR / ADE.