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[目的 ]探讨日本血吸虫成虫表膜抗原 (Sj MAg)检测日本血吸虫病患者的特异性和敏感性及考核疗效价值。 [方法 ]采用 Sj MAg- EL ISA检测治疗前、后不同时期血吸虫病患者血清中特异性 Ig G、 Ig G4及健康人、并殖吸虫、华支睾吸虫及囊尾蚴病患者血清中的交叉抗体。 [结果 ]Sj MAg的敏感性和特异性与可溶性虫卵抗原(Sj SEA)比较 ,无显著性差异 (P>0 .0 5 ) ;用 Sj MAg- EL ISA检测治疗后 12个月患者血清中 Ig G的阴转率为80 .0 % ,显著高于 SEA- EL ISA的 43.3% ,而检测 Ig G4的阴转率为 93.3% ,显著高于 Sj SEA- EL ISA的 6 0 % ,检测治疗后 2 4个月患者血清中 Ig G和 Ig G4的阴转率分别达 92 .9%和 97.6 %。 [结论 ]Sj MAg- EL ISA检测日本血吸虫病具有与 Sj SEA- EL ISA相同的诊断价值和较高的考核疗效价值。
[Objective] To investigate the specificity and sensitivity of Schistosoma japonicum adult schistosoma japonicum surface antigen (Sj-MAg) in detecting schistosomiasis japonica and evaluate its curative effect. [Method] The serum levels of specific Ig G, Ig G4 and healthy, Paragonimus, Clonorchis sinensis and cysticercosis patients in serum from patients with schistosomiasis before and after treatment were detected by Sj-MAg-ELISA. . [Results] The sensitivity and specificity of Sj-MAg were not significantly different from that of Sj-SEA (P> 0.05). Serum levels of Sj-MAg The negative conversion rate of Ig G was 80.0%, which was significantly higher than that of SEA-EL ISA 43.3%, while that of Ig G4 was 93.3%, significantly higher than that of Sj SEA-EL ISA 60% In the latter 24 months, the negative conversion rates of Ig G and Ig G4 in serum were 92.9% and 97.6%, respectively. [Conclusion] Sj-MAg-EL ISA detection of schistosomiasis japonica has the same diagnostic value as Sj SEA-EL ISA and high evaluation value.