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目的探讨S100p蛋白在胰腺癌组织中的表达及其临床意义。方法应用免疫组化SP法检测58例胰腺癌组织中S100p蛋白的表达情况,分析其与临床病理因素的关系及对胰腺癌预后的影响。结果在胰腺癌组织中S100p蛋白的表达率为87.9%(51/58),而在胰腺癌旁组织中S100p蛋白无表达;S100p蛋白在癌组织中表达明显高于癌旁组织,差异有统计学意义(P<0.05)。S100p表达与胰腺癌的组织分化程度、临床分期、淋巴结转移有关;该3因素的分组间均有统计学差异(P<0.05)。S100p在胰腺癌组织中的表达与患者预后有关;S100p阴性组胰腺癌患者与阳性组生存曲线有明显差别,前者的预后明显优于后者。结论 S100p在胰腺癌发生、发展中发挥重要作用,可能成为诊断胰腺癌新的标志物以及判断其生物学行为、预测转移趋势的指标。
Objective To investigate the expression of S100p protein in pancreatic cancer and its clinical significance. Methods The expression of S100p protein in 58 cases of pancreatic cancer was detected by immunohistochemical SP method. The relationship between S100p protein and clinical pathological factors and the prognosis of pancreatic cancer were analyzed. Results The expression of S100p protein in pancreatic cancer tissues was 87.9% (51/58), while there was no expression of S100p protein in pancreatic cancer tissues. The expression of S100p protein in cancer tissues was significantly higher than that in paracancerous tissues Significance (P <0.05). The expression of S100p was correlated with the degree of pancreatic cancer tissue differentiation, clinical stage and lymph node metastasis. There was a significant difference between the three groups (P <0.05). S100p in pancreatic cancer tissue expression and prognosis of patients; S100p negative group of patients with pancreatic cancer and positive survival curve was significantly different, the former prognosis was significantly better than the latter. Conclusion S100p plays an important role in the development and progression of pancreatic cancer and may be a new marker for diagnosis of pancreatic cancer and an indicator of its biological behavior and prognosis.