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本文对八氯二丙醚(S_2)原液及其所制蚊香进行毒性毒理学研究。结果表明,S_2属低毒物质,致突变试验阴性。S_2蚊香亦为低毒物质,但在Ames试验中,TA_(100)-S_9的2.0和4.0mg/L两个浓度出现阳性反应;小鼠DNA合成抑制试验,2.73mg/L浓度组对肺和睾丸的DNA合成有影响;蓄积系数K>8,为弱蓄积物质;亚急性毒性试验,各项指标无异常改变。
In this paper, eight chlorine dipropyl ether (S_2) stock solution and the mosquito made of toxic toxicological study. The results showed that S_2 is a low-toxic substance and the mutagenicity test was negative. S_2 mosquito was also a low toxicity substance, but Ames test, TA_ (100) -S_9 2.0 and 4.0mg / L two concentrations appeared positive reaction; DNA synthesis inhibition test in mice, 2.73mg / L concentration of lung and Testis DNA synthesis has an impact; accumulation coefficient K> 8, is a weak accumulation of substances; subacute toxicity test, the indicators without abnormal changes.