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目的探讨康艾注射液在晚期食管癌化疗中的减毒增效作用。方法选取同步放化疗+康艾注射液治疗的40例晚期食管癌患者为观察组,仅采用同步放化疗的40例晚期食管癌患者为对照组。比较两组患者的疗效、免疫功能、毒副反应以及生活质量。结果观察组的总有效率为60.0%高于对照组的37.5%,差异具有统计学意义(P<0.05)。观察组治疗后的CD4+、CD8+/CD4+高于对照组,CD8+低于对照组,差异具有统计学意义(P<0.05)。观察组的毒副反应程度轻于对照组,各方面的生活质量评分好于对照组,差异具有统计学意义(P<0.05)。结论康艾注射液能够提高晚期食管癌同步放化疗的治疗效果,减轻治疗的毒副反应,改善患者的生活质量。
Objective To investigate the attenuated synergies of Kangai injection in the treatment of advanced esophageal cancer. Methods Forty patients with advanced esophageal cancer treated with chemoradiotherapy + Kang Ai injection were selected as the observation group. Forty patients with advanced esophageal cancer treated with concurrent chemoradiotherapy were selected as the control group. The curative effect, immune function, side effects and quality of life of the two groups were compared. Results The total effective rate in observation group was 60.0% higher than that in control group (37.5%), the difference was statistically significant (P <0.05). The levels of CD4 + and CD8 + / CD4 + in the observation group were significantly higher than those in the control group and CD8 + group (P <0.05). The toxicity of the observation group was lighter than that of the control group, and the quality of life scores of all the groups were better than that of the control group (P <0.05). Conclusions Kangai injection can improve the therapeutic effect of concurrent chemoradiotherapy in advanced esophageal cancer, relieve the side effects of treatment and improve the quality of life of patients.