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目的:优化挤出滚圆法制备山楂叶总黄酮微丸的处方工艺。方法:采用挤出滚圆法制备山楂叶总黄酮微丸,以微丸的物理性质及总黄酮的溶出度为考察指标,对处方因素进行筛选,并采用正交实验设计对工艺参数进行优化。结果:最佳工艺条件为以MCC、乳糖为填充剂,药粉含量为50%,挤出速度为100r/min,滚圆转速为1 000r/min,滚圆时间为10min,制得微丸圆整度、收率、溶出均理想。结论:挤出滚圆法可用于制备中药微丸,该工艺简便可行,所得微丸质量好,值得推广。
Objective: To optimize the preparation process of hawthorn leaf flavonoids pellets by extrusion spheronization. Methods: The hawthorn leaf flavonoids pellets were prepared by extrusion-spheronization. The physical properties of pellets and the dissolution of flavonoids were investigated. The prescription factors were screened. The orthogonal design was used to optimize the process parameters. Results: The optimum conditions were as follows: MCC, lactose as filler, the content of drug powder was 50%, the extrusion speed was 100r / min, the spinner speed was 1 000r / min and the spheronization time was 10min, Yield, dissolution are ideal. Conclusion: Extrusion spheronization method can be used to prepare Chinese medicine pellets, the process is simple and feasible, the quality of the pellets obtained is worthy of promotion.