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目的了解新沂市婴儿OPV(口服脊髓灰质炎减毒活疫苗)基础免疫的效果,探索脊髓灰质炎(脊灰)母传抗体对OPV效果评价的影响。方法以2009-2011年新沂市198名2月龄婴儿作为研究对象,OPV基础免疫,免疫前和免疫后1个月分别采集静脉血2 ml,采用微量中和法检测血清中Ⅰ、Ⅱ、Ⅲ型脊灰的中和抗体,评价免疫效果。结果 2009-2011年的198名婴儿中,Ⅰ、Ⅱ、Ⅲ型脊灰中和抗体的免疫后阳性率除2010年的Ⅲ型脊灰中和抗体为89.23%外,均能达到98%以上。Ⅰ、Ⅱ、Ⅲ型脊灰免疫前中和抗体滴度<1∶8时,免疫后GMI(几何平均增长倍数)2009-2011年分别为357.74、279.71、93.75,288.67、185.07、50.09,138.64、139.32、43.60;免疫前滴度1∶8~<32时,GMI分别为58.71、42.24、33.34,92.04、61.91、2.94,46.17、27.71、10.84;免疫前滴度1∶32~1∶128时,GMI分别为5.34、21.77、5.66,4.59、8.00、1.80,10.68、14.49、1.15。结论脊灰母传抗体对其免疫效果有一定的干扰,母传抗体滴度越高免疫后抗体增长倍数越小。
Objective To understand the effect of basic immunization of infant OPV (live attenuated oral polio vaccine) in Xinyi City and explore the effect of poliovirus (polio) mother-antibody on OPV evaluation. METHODS: A total of 198 2-month-old infants from 2009 to 2011 in Xinyi City were enrolled in this study. Primary immunization of OPV, 2 ml of venous blood were collected before immunization and 1 month after immunization. Serum levels of Ⅰ, Ⅱ, Ⅲ type polio neutralizing antibodies to evaluate the immune effect. Results Among the 198 infants from 2009 to 2011, the positivity rates of neutralizing antibodies against type Ⅰ, Ⅱ and Ⅲ of poliovirus were above 98% except for 89.23% of neutralizing antibodies against type Ⅲ poliovirus in 2010. The mean GMI (geometric mean multiple of growth) after immunization was 357.74, 279.71, 93.75, 288.67, 185.07, 50.09, 138.64 respectively from 2009 to 2011 when the titers of neutralizing antibodies of type I, II and III before immunization were less than 1: 139.32 and 43.60, respectively. Before immunization, the GMIs were 58.71, 42.24, 33.34, 92.04, 61.91, 2.94, 46.17, 27.71 and 10.84, respectively. Before titration 1:32 to 1:128, GMI were 5.34,21.77,5.66,4.59,8.00,1.80,10.68,14.49,1.15. Conclusion The poliovirus antibody has a certain interference with its immune effect. The higher the antibody titer of mother antibody, the smaller the antibody growth fold after immunization.