论文部分内容阅读
目的:观察引发妊娠期肝内胆汁淤积症可能的影响因素,以及不同妊娠时限发病对产妇及胎儿结局的影响。方法:选取2012年1月~2013年6月在我院进行治疗的105例妊娠期肝内胆汁淤积症患者作为病例组,110例正常孕妇为对照组。分析两组患者的病历资料,对本病相关危险因素进行对照研究,筛选其高危因素。同时将病例组患者按发病时不同孕周分为早发组(<28周发病,42例)和晚发组(≥28周发病,63例),比较两组患者胎儿预后情况。结果:病例组患者ICP家族史、高雌激素水平、乙肝病毒感染、免疫失调、硒摄入量偏低等因素与对照组比较差异具有统计学意义(P<0.05);而是否初次妊娠、锌摄入量偏低、农药暴露情况等因素两组比较并无统计学意义(P>0.05)。同时,早发组发生羊水污染、胎儿窘迫、早产、围生儿死亡、低体重儿的几率均显著高于晚发组,差异具有统计学意义(P<0.05)。结论:ICP家族史、高雌激素水平、乙肝病毒感染、免疫失调、硒摄入量偏低等因素为ICP发病的高危因素,ICP发生时间越早对胎儿的不利影响越严重。
OBJECTIVE: To observe the possible influencing factors of intrahepatic cholestasis of pregnancy and the effects of different stages of pregnancy on maternal and fetal outcomes. Methods: 105 patients with intrahepatic cholestasis of pregnancy who were treated in our hospital from January 2012 to June 2013 were selected as the case group and 110 normal pregnant women as the control group. Analysis of the two groups of patients medical records, the disease-related risk factors for controlled study, screening for its risk factors. At the same time, patients in the case group were divided into two groups: early onset group (<28 weeks) and late onset group (≥28 weeks, 63 cases) according to different gestational age at onset. The prognosis of fetuses in both groups were compared. Results: There were significant differences in ICP family history, high estrogen level, hepatitis B virus infection, immune disorders, low selenium intake and other factors in the case group as compared with those in the control group (P <0.05) Low intake, pesticide exposure and other factors were no significant difference between the two groups (P> 0.05). At the same time, the incidence of amniotic fluid contamination, fetal distress, premature birth, perinatal death and low birth weight infants in early-onset group were significantly higher than those in late-onset group, the difference was statistically significant (P <0.05). CONCLUSION: ICP family history, high estrogen level, hepatitis B virus infection, immune disorders and low intake of selenium are the risk factors of ICP. The earlier the occurrence of ICP, the worse the adverse effects on the fetus.