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目的 探讨普宁地区育龄妇女孕前优生健康检查梅毒筛查干预模式在降低出生缺陷,提高孕育质量的作用评估.方法 回顾性分析普宁地区2012—2016年间12420名参加国家免费孕前优生健康检查的育龄妇女的临床资料,分析其梅毒筛查的实验室结果以及对梅毒患者的治疗状况,并随访所生育后代的健康状况,评估梅毒筛查干预模式在降低出生缺陷,提高孕育质量的作用.结果 12420名育龄妇女的梅毒筛查结果为:梅毒螺旋体抗体(胶体金法)检测52例阳性,初筛阳性率为0.42％;将初筛阳性的样本再进行梅毒甲苯胺红不加热血清试验(TRUST)检测确诊44例阳性,阳性率为0.35％.经过干预治疗后,44例梅毒患者中有39例患者在随访期间有生育后代,子代中均未发现梅毒携带或感染病例.结论 免费孕前优生健康检查对优生优育具有重要意义,孕前进行必要的梅毒筛查并进行干预是提高人口素质,降低出生缺陷的有效手段,值得推广.“,”Objective To investigate the effect of syphilis screening intervention mode on reducing birth defects and improving the quality of gestation in women of childbearing age in Puning area. Methods The clinical data of 12 420 women of childbearing age who participated in the national free pre-pregnancy eugenics examination in Puning area from 2012 to 2016 were retrospectively analyzed. The laboratory results of syphilis screening and the treatment status of syphilis patients were analyzed, and the health of the offspring was followed up, assess the role of syphilis screening intervention mode in reducing birth defects and improving the quality of gestation. Results The results of syphilis screening in 12 420 women of childbearing age were as follows: 52 cases of syphilis antibody (colloidal gold method) were positive, and the initial screening rate was 0.42%. The samples with positive screening were further tested with syphilis toluidine red unheated serum (TRUST) was confirmed to be positive in 44 cases, with a positive rate of 0.35%. After intervention, 39 0f the 44 patients with syphilis had fertility offspring during the follow-up period, and no syphilis carriers or infections were found in the off-spring. Conclusion The free pre-pregnancy eugenics health check is of great significance for prenatal and postnatal care. Performing necessary syphilis screening and intervention before pregnancy is an effective means to improve the quality of the population and reduce birth defects. It is worth promoting.