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目的:研究吲哒帕胺联合厄贝沙坦对高血压合并早期肾功能损害的临床治疗效果。方法:选择于我院就诊的高血压合并早期肾损害患者124例,随机分为两组,各62例。对照组单用吲达帕胺,治疗组吲达帕胺联合使用厄贝沙坦。分别于治疗前,治疗后4周,治疗后8周监测患者血压、24h尿蛋白定量、血尿酸、血肌酐、血钾。对比两组之间的差异。结果:治疗后4周治疗组舒张压、收缩压均低于对照组,治疗组血钾高于对照组,两组之间24 h尿蛋白定量、血尿酸、血肌酐对比无统计学差异。治疗后8周治疗组舒张压、收缩压均低于对照组,治疗组血钾高于对照组,治疗组24 h尿蛋白定量、血尿酸均低于对照组,两组之间血肌酐对比无统计学差异。结论:厄贝沙坦和吲达帕胺联合治疗高血压合并早期肾功能损害效应互补,效果良好,副作用小,是一种较好的联合降压方案。
Objective: To study the clinical effect of indapamide combined with irbesartan in the treatment of hypertension complicated with early renal dysfunction. Methods: A total of 124 patients with hypertension and early renal damage who were selected for treatment in our hospital were randomly divided into two groups (n = 62). Indapamide was used alone in the control group, and irbesartan was used in combination with indapamide in the treatment group. Blood pressure, 24h urinary protein, serum uric acid, serum creatinine and serum potassium were monitored before treatment, 4 weeks after treatment and 8 weeks after treatment. Compare the differences between the two groups. Results: After 4 weeks of treatment, the diastolic pressure and systolic blood pressure in the treatment group were lower than those in the control group. The serum potassium level in the treatment group was higher than that in the control group. There was no significant difference in 24 h urinary protein, serum uric acid and serum creatinine between the two groups. After 8 weeks of treatment, the diastolic blood pressure and systolic blood pressure in the treatment group were lower than those in the control group. The serum potassium level in the treatment group was higher than that in the control group. The 24-hour urinary protein and serum uric acid in the treatment group were lower than those in the control group Statistical differences. Conclusion: Irbesartan and indapamide combined treatment of hypertension with early renal dysfunction complementary effect with good side effects, is a good combination of antihypertensive regimen.