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随机选择T2DM患者60例,根据UA/Cr的比值分为3组:<30mg/g的NA(22例);30～300mg/g的mA组(20例);>300mg/g的MA组(18例)。NC组30例为正常健康体检者。结果NA组血清sICAM-1高于NC组P<0.05;mA组高于NA组P<0.05;MA组最高。血清sICAM-1水平与UA/Cr比值、HbA1c及CRP呈正相关(分别为r=0.89,r=0.76,r=0.68);与年龄、性别、病程及胆固醇无相关性。逐步回归分析显示:血清sICAM-1受UA/Cr比值、HbA1c、CRP影响较大。结论提示sICAM-1可能参与了DN的发生与发展。
60 patients with T2DM were randomly selected and divided into 3 groups according to the ratio of UA / Cr: NA of <30mg / g (22 cases), mAb of 30 ~ 300mg / g (20 cases) and MA group of> 300mg / g 18 cases). NC group of 30 cases of normal health examination. Results Serum sICAM-1 level in NA group was significantly higher than that in NC group (P <0.05), while that in NA group was higher than that in NA group (P <0.05). MA group was the highest. Serum levels of sICAM-1 were positively correlated with UA / Cr ratio, HbA1c and CRP (r = 0.89, r = 0.76, r = 0.68, respectively), but not with age, sex, duration of disease and cholesterol. Stepwise regression analysis showed that serum sICAM-1 was significantly affected by UA / Cr ratio, HbA1c and CRP. Conclusions sICAM-1 may be involved in the occurrence and development of DN.