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经活化的肺泡巨噬细胞(PAM)能抑制Hela细胞的增殖,其细胞毒性指数为57.90±2.48(P<0.01)。PAM的这种细胞毒功能可被大气飘尘(AP)降低,在AP浓度为10~100μg/ml范围内这种降低作用显示剂量-反应关系,在10、50、100μg/mlAP作用下,PAM对Hela细胞的细胞毒指数分别为51.91±3.67(P>0.05)、40.83±2.14(P<0.01)、32.33±4.55(P<0.01)。在500μg/mlAP作用下,由于大量的PAM脱落和死亡,其细胞毒指数仅为14.98±3.29(P<0.01)。提示大气飘尘具有降低肺巨噬细胞抗肿瘤免疫的作用。
Activated alveolar macrophages (PAMs) inhibited Hela cell proliferation with a cytotoxicity index of 57.90 ± 2.48 (P <0.01). This cytotoxicity of PAM was reduced by atmospheric airborne dust (AP). The dose-response relationship was shown in the range of 10-100 μg / ml of AP. Under the action of 10, 50 and 100 μg / ml AP, The cytotoxicity index of Hela cells were 51.91 ± 3.67 (P> 0.05), 40.83 ± 2.14 (P <0.01) and 32.33 ± 4.55 (P <0. 01). At a concentration of 500 μg / ml AP, the cytotoxicity index was only 14.98 ± 3.29 (P <0.01) due to a large amount of PAM shedding and death. Prompted airborne dust has the effect of reducing anti-tumor immunity of lung macrophages.