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目的:观察生脉注射液在恶性肿瘤化疗中减轻骨髓抑制、恶心呕吐等毒副反应的疗效。方法:治疗组采用生脉注射液60ml+5%葡萄糖500ml静脉滴注,每日1次,连用15天为1周期,在化疗开始前2天开始用药。对照组仅用化疗。所有病例均接受2周期化疗。结果:治疗组白细胞降低的例数及程度都明显优于对照组,两组有显著性差异(P<0.05)。治疗组与对照组在恶心、呕吐反应方面无显著性差异(P>0.05),但治疗组重度呕吐比例稍低。结论:生脉注射液在恶性肿瘤化疗时对骨髓抑制和胃肠道反应都有明显的预防和治疗作用,该药对中晚期肿瘤患者的化疗减毒有效。
Objective: To observe the effect of Shengmai injection in reducing the bone marrow suppression, nausea, vomiting and other toxic side effects in the chemotherapy of malignant tumors. Methods: The treatment group with Shengmai injection 60ml + 5% glucose 500ml intravenous infusion, once daily, once every 15 days for a period of two days before the start of chemotherapy medication. Control group only with chemotherapy. All cases received 2 cycles of chemotherapy. Results: The number and extent of leukopenia in the treatment group were significantly better than those in the control group, with significant difference between the two groups (P <0.05). There was no significant difference between the treatment group and the control group in nausea and vomiting (P> 0.05), but the rate of severe vomiting in the treatment group was slightly lower. Conclusion: Shengmai injection has obvious preventive and therapeutic effects on myelosuppression and gastrointestinal tract reaction in the chemotherapy of malignant tumors. The drug is effective in attenuating chemotherapy in advanced cancer patients.