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用小白鼠急性死亡率法测定了山莨菪碱ip时的经时过程和药动学参数。山莨菪碱在小鼠体内的经时过程为二室开放模型,1.5h之前为分布相,1.5h之后为消除相。用最小二乘法和残余量法求得α、β、A和B四项表现动力学参数分别为3.608h~(-1),0.238h~(-1),529mg/kg(200.2％)和 95mg/kg(35.9％);按药动学公式分别求得分布相表观半寿期(t_(1/2)α)和消除相表现半寿期(t_(1/2)β)为0.2h和2.9h,表观转运速率常数k_(12),k_(21)和k_(10)分别为1.952h~(-1),0.749h~(-1)和1.144h~(-1);表观曲线下面积(AUC)是546mg.h/kg;表观清除率(CI)是0.48kg/(kg.h),表观分布容积V_c,V_p,V_t,和V_b分别为0.42kg/kg,1.10kg/kg,1.53kg/kg和2.04kg/kg.
Time course and pharmacokinetic parameters of anisodamine ip were determined by the acute death rate of mice. Anisodamine in mice in the passage of time for the two-compartment open model, 1.5h before the distribution phase, after 1.5h to eliminate the phase. The kinetic parameters of α, β, A and B obtained by least square method and residual method were 3.608 h -1, 0.238 h -1, 529 mg / kg and 200 mg respectively / kg (35.9%). According to the pharmacokinetic formula, the apparent phase half life (t_ (1/2) α) and the phase half life (t_ (1/2) β) And 2.9h, respectively. The apparent transport rate constants k_ (12), k_ (21) and k_ (10) were 1.952 h -1, 0.749 h -1 and 1.144 h -1, respectively. The apparent area under the curve (AUC) was 546 mg.h / kg; the apparent clearance (CI) was 0.48 kg / kg.h and the apparent volume of distribution V_c, V_p, V_t and V_b were 0.42 kg / kg, 1.10 kg / kg, 1.53 kg / kg and 2.04 kg / kg.