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Microbial transformation of diosgenin(1) by Syncephalastrum racemosum yielded five new polar metabolites,which wereidentified as(25R)-spirost-5-en-3β,7α,9α-triol-12-one(2),(25R)-spirost-5-en-3β,9α,12α-triol-7-one(3),(25R)-spirost-5-en-3β,9α-diol-7,12-dione(4),(25R)-spirost-4-en-9α,12β,14α-triol-3-one(5),and(25S)-spirost-4-en-9α,14α,25β-triol-3-one(6).Compounds 1-6 exhibited moderate cytotoxicity against K562 cells and among them compounds 2,3,and 6 were more potentthan the parent compound 1.
Microbial transformation of diosgenin (1) by Syncephalastrum racemosum yielded five new polar metabolites, which were identified as (25R) -spirost-5-en-3beta, 7alpha, 9alpha- triol- 12-one (25R) (25R) -spirost-5-en-3β, 9α-diol-7,12-dione (4) 4-en-9α, 12β, 14α-triol-3-one (5), and (25S) -spirost-4-en-9α, 14α, 25β-triol- moderate cytotoxicity against K562 cells and among them compounds 2,3, and 6 were more potentthan the parent compound 1.