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目的探讨PTEN与survivin在胃印戒细胞癌中的表达及其意义。方法用免疫组化检测73例胃印戒细胞癌手术切除标本和癌旁组织PTEN、survivin的表达,分析两者与临床病理特征的关系。结果PTEN在胃印戒细胞癌中的表达率明显低于癌旁组织(P<0.01),其表达与淋巴结转移、器官转移、浸润深度、TNM分期具有相关性(P<0.05);survivin在癌组织中表达率为63%(46/73),癌旁组织均为(-),与淋巴结转移、器官转移、浸润深度、TNM分期呈显著正相关(P<0.01)。PTEN与survivin的表达呈负相关(r=-0.404,P<0.01)。Kaplan-Meier分析显示,PTEN阴性组3年生存率显著低于阳性组(P<0.01),survivin阳性组3年生存率显著低于阴性组(P<0.01)。Cox回归模型多因素分析显示,PTEN表达是胃印戒细胞癌的独立预后因素。结论PTEN和survivin的表达可能与胃印戒细胞癌的发生、发展密切相关,二者可作为评价胃印戒细胞癌预后的指标,对胃印戒细胞癌的治疗具有重要意义。
Objective To investigate the expression of PTEN and survivin in gastric signet-ring cell carcinoma and its significance. Methods Immunohistochemistry was used to detect the expression of PTEN and survivin in 73 cases of signet ring cell carcinoma of the stomach and their adjacent tissues. The relationship between them and clinicopathological features was analyzed. Results The expression of PTEN in gastric signet-ring cell carcinoma was significantly lower than that in paracancerous tissues (P <0.01), and the expression of PTEN was correlated with lymph node metastasis, organ metastasis, depth of invasion and TNM stage (P <0.05) The positive rates of expression in tissues were 63% (46/73) and adjacent tissues (-), respectively, which were positively correlated with lymph node metastasis, organ metastasis, depth of invasion and TNM stage (P <0.01). PTEN and survivin expression was negatively correlated (r = -0.404, P <0.01). Kaplan-Meier analysis showed that the 3-year survival rate of PTEN negative group was significantly lower than that of positive group (P <0.01). The 3-year survival rate of survivin positive group was significantly lower than that of negative group (P <0.01). Cox regression model multivariate analysis showed that PTEN expression is an independent prognostic factor of gastric signet-ring cell carcinoma. Conclusions The expression of PTEN and survivin may be closely related to the occurrence and development of gastric signet ring cell carcinoma. Both of them may be used as indicators to evaluate the prognosis of gastric signet ring cell carcinoma, which is of great significance for the treatment of gastric signet ring cell carcinoma.