论文部分内容阅读
目的探讨蒲元和胃胶囊联合铋剂四联疗法治疗幽门螺杆菌相关性胃炎的临床疗效。方法选取平邑县中医医院2014年5月—2016年6月收治的幽门螺杆菌相关性胃炎患者80例,随机分为对照组和治疗组,各40例。对照组患者采用铋剂四联疗法,治疗组患者在对照组基础上给予蒲元和胃胶囊,两组患者均持续治疗14 d。比较两组患者的临床疗效、幽门螺杆菌清除率及治疗前后腹胀、少食症状评分,并观察患者不良反应发生情况。结果治疗组患者临床疗效优于对照组(P<0.05)。两组患者幽门螺杆菌清除率比较,差异无统计学意义(P>0.05)。治疗前,两组患者腹胀、少食评分比较,差异无统计学意义(P>0.05);治疗后,治疗组患者腹胀、少食评分低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用蒲元和胃胶囊联合铋剂四联疗法治疗幽门螺杆菌相关性胃炎临床疗效确切,可有效改善患者的临床症状,提升幽门螺杆菌根除率,且安全性好。
Objective To investigate the curative effect of Pu Yuan Hewei Capsule combined with bismuth quadruple therapy on Helicobacter pylori-associated gastritis. Methods Eighty patients with Helicobacter pylori-associated gastritis who were treated in Pingyi Hospital of Traditional Chinese Medicine from May 2014 to June 2016 were randomly divided into control group and treatment group, 40 cases each. Patients in the control group were treated with bismuth quadruple therapy. The patients in the treatment group were treated with Puyuanhewei Capsule on the basis of the control group, and the patients in both groups were treated for 14 days. The clinical curative effect, Helicobacter pylori eradication rate, abdominal distension and underage symptom score before and after treatment were compared between the two groups, and the incidence of adverse reactions was observed. Results The clinical efficacy of the treatment group was better than that of the control group (P <0.05). There was no significant difference in Helicobacter pylori clearance between the two groups (P> 0.05). Before treatment, there was no significant difference between the two groups in the rate of bloating and eating less food (P> 0.05). After treatment, the bloating and eating less score of the treatment group was lower than that of the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusions The clinical efficacy of PUYUANHE WEI capsule combined with bismuth quadruple therapy in the treatment of Helicobacter pylori-associated gastritis is accurate, which can effectively improve the clinical symptoms, improve the eradication rate of Helicobacter pylori and have good safety.