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The-main-objective-of-this-study-is-to-numerically-investigate-the-characteristics-of-ultimate-compressive-strength-of-stiffened-panels-with-opening-and-also-to-fit-the-design-oriented-formulae.-For-this-purpose,-three-series-of-well-executed-experimental-data-on-longitudinally-stiffened-steel-plates-with-and-without-opening-subjected-to-the-uniform-axial-in-pane-load-which-is-carried-out-to-study-the-buckling-and-post-buckling-up-to-the-final-failure-are-chosen.-Also,-a-nonlinear-finite-element-method-capable-of-efficiently-analyzing-the-large-elasto-plastic-deflection-behavior-of-stiffened-panels-is-developed-and-used-for-simulation.-The-feasibility-of-the-present-simulation-process-is-confirmed-by-a-good-agreement-with-the-experimental-results.-More-case-studies-are-developed-employing-the-simulation-process-to-analyze-the-influence-of-various-design-variables-on-the-reduction-rate-of-ultimate-strength-of-stiffened-panel-induced-by-opening.-Based-on-the-computed-results,-two-design-formulae-are-fitted-and-the-accuracy-of-design-formulae-is-studied.-Furthermore,-the-viability-of-the-design-formulae-for-practical-engineering-is-proved.