目的:探讨围产因素对早期新生儿血清C-反应蛋白(CRP)检测的影响。方法:在490例早期新生儿血清CRP阳性者中,遴选非感染病例226例,分析围产因素与其检测结果的关系。结果:分娩方式与CRP检测结果密切相关,剖腹产的阳性率明显高于顺产,钳产或吸引产更显著高于顺产,生后窒息及高龄产妇的CRP阳性率也明显高于对照组,不同性别及胎儿成熟度之间的CRP检测结果无明显异差。结论:诊断早期新生儿感染不应过分依重CRP检测结果,应与临床、实验室及细菌学检查结合,以免造成滥用抗菌素。 Objective: To investigate the influence of perinatal factors on serum C-reactive protein (CRP) detection in early neonates. Methods: Among 490 cases of early neonates with serum CRP positive, 226 noninfectious cases were selected and the relationship between perinatal factors and their test results was analyzed. Results: The mode of delivery was closely related to the results of CRP. The positive rate of caesarean section was significantly higher than that of cesarean section. The positive rate of CRP in cesarean section or midwifery was significantly higher than that in the control group And fetal maturity CRP test results between no significant difference. CONCLUSIONS: Early diagnosis of neonatal infection should not be overly relying on CRP test results and should be combined with clinical, laboratory and bacteriological tests to avoid abuse of antibiotics.