论文部分内容阅读
为阐明功能性α２－肾上腺素受体（α２－ＡＲ）的特性及其与α１－ＡＲ的相互关系，以离体大鼠主动脉为模型，进行收缩功能实验。发现在大鼠主动脉中，α１－ＡＲ和α２－ＡＲ均可介导其收缩效应并以α１－ＡＲ的作用为主。α１－ＡＲ可增强α２－ＡＲ介导的收缩效应，而α２－ＡＲ则对α１－ＡＲ介导的收缩效应无影响。在不可逆阻断α１－ＡＲ而保留α２－ＡＲ的条件下，α２－ＡＲ介导的缩血管效应消失，仅在阈值浓度的ＫＣＩ存在下才能显示，且收缩旧度较对照显著降低。结果表明，在离体大鼠主动脉中存在功能性α２－ＡＲ，α２－ＡＲ的缩血管作用依赖于。α１－ＡＲ的激动，其最大收缩反应远远小于α１－ＡＲ。
To elucidate the characteristics of functional α2-adrenergic receptor (α2-AR) and its relationship with α1-AR, an isolated rat aorta was used as a model for contractile function test. It was found that both α1-AR and α2-AR mediate their contractile effects in the aorta of rats and are dominated by α1-AR. α1-AR enhanced α2-AR-mediated contractile effects, while α2-AR had no effect on α1-AR-mediated contractile effects. Α2-AR-mediated vasoconstriction disappeared when irreversible blocking of α1-AR and retention of α2-AR, which could only be shown in the presence of KCI at a threshold concentration, and the old degree of shrinkage was significantly lower than that of the control. The results showed that vasoconstrictive effects of α2-AR and α2-AR existed in isolated rat aorta. The maximal contractile response of α1-AR is far less than that of α1-AR.