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目的研制一种能预防铅中毒的食用保健盐。方法用含0．25％醋酸铅的饮料喂养SD大鼠复制铅中毒模型，并同时用不同浓度高碘盐水分组喂饮．其三组的KI摄入量各自分别为10mg·kg／日．20mg·kg／日和30mg·kg/日．探索预防铅中毒的KI日需量。然后制成含KI1％的食盐，供50名铅作业人烹饪菜肴后食用。服用盐前后测定血EPP、Hb、血铅、尿δ-ALA，并动态观察尿铅排泄情况。结果动物实验显示日需KI10mg·kg／日则具有抗铅性损害作用，临床研究显示服高碘盐后第3天排铅量增加，第9天达高峰第四周达正常，服用高碘盐前后Hb，ZPP、δ－ALA、血Ph、NAG、Rp依次为101．2和128g／L，P＝0，05，7．5和1．73μol／L，p＜0，01，123．12和65．36μmol／LP＜0．05，21．23和8．5μmol／L，P＜0．05，20．9和6．7u／LP＜0．01，1．5和0．34μmg／LP＜0．05。结论铅接触人员摄入1％KI的食盐有驱铅预防铅性损害作用。
Objective To develop a kind of edible salt that can prevent lead poisoning. Methods SD rats were fed with 0.25% lead acetate to replicate lead poisoning model and fed with high iodine salt water of different concentration at the same time. KI intake of the three groups were 10mg · kg / day respectively. 20 mg · kg / day and 30 mg · kg / day. Explore the daily dose of KI to prevent lead poisoning. It is then made into salt containing KI1% for consumption by 50 lead workers after cooking the dishes. The levels of EPP, Hb, blood lead and urine δ-ALA were measured before and after taking salt, and the urinary lead excretion was observed dynamically. The results of animal experiments showed that daily KI10mg · kg / day is anti-lead damage, clinical studies have shown that high doses of iodized salt after the first three days to increase the amount of lead on the 9th day reached the fourth week of peak normal, taking high iodized salt The levels of Hb, ZPP, δ-ALA, blood Ph, NAG and Rp before and after were 101.2 and 128g / L, P = 0,05,7.5 and 1.73μol / L respectively, p <0,01,123.12 And 65.36 μmol / LP <0.05, 21.23 and 8.5 μmol / L, P <0.05, 20.9 and 6.7 u / LP <0.01, 1.5 and 0.34 μmg / LP <0.05. Conclusion Exposure of lead to 1% KI in lead exposure may lead to prevent lead damage.