同时检测人体尿液中三甲基氯化锡和盐酸氯丙嗪含量的GC/MS分析法探讨

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三甲基氯化锡作为无铅塑料的稳定剂、防腐剂的替代品,广泛地用于塑料工业中。三甲基氯化锡具有高度毒性,可通过呼吸道、消化道和皮肤黏膜进入人体,然后主要经尿样和粪便排出[1]。氯丙嗪,又称冬眠灵,属于吩噻嗪类,是抗精神病类药中的经典性药物。氯丙嗪的主要作用机理是通过阻断脑内多巴胺受体而产生镇静作用,在体内代谢主要是氧化过程,受 Trimethyltin chloride is widely used in the plastics industry as a stabilizer for lead-free plastics and as a substitute for preservatives. Trimethyltin chloride is highly toxic and can enter the human body through the respiratory tract, digestive tract and mucocutaneous lining and is then mainly excreted through urine and feces [1]. Chlorpromazine, also known as winter sleep Ling, belonging to phenothiazines, antipsychotic drugs in the classic drug. The main mechanism of action of chlorpromazine is to sedative effect by blocking dopamine receptors in the brain, metabolism in the body is mainly the oxidation process, by
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