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目的:探讨高功能孤独障碍患儿与正常儿童在结构磁共振成像上感兴趣脑区组织密度的差异。方法:在SPM平台上使用Anatomy工具箱测量了18名年龄6～14岁的高功能孤独障碍患儿和16名年龄、性别、智商、身高、体重与之相匹配的正常对照儿童结构磁共振成像上感兴趣脑区的组织密度。结果:高功能孤独障碍患儿左侧初级视觉皮层V1区的组织密度显著大于正常对照组(P<0.005);双侧海马内嗅皮质、右侧杏仁基底外侧核的组织密度显著小于正常对照组(P<0.005)。结论:学龄高功能孤独障碍患儿枕叶视觉皮层以及边缘系统的脑组织密度存在多处异常。
Objective: To investigate the difference of brain tissue density in structural magnetic resonance imaging between children with high-functioning solitary disorder and normal children. Methods: Anatomy kit was used to measure 18 children aged 6-14 years with high-functioning children with autism disorder and 16 children with age, sex, IQ, height, weight and matched normal control children’s structural magnetic resonance imaging The brain tissue density of interest. Results: Tissue densities of V1 area in the left primary visual cortex in children with high-functioning solitary disorder were significantly higher than those in the normal control group (P <0.005). The density of the bilateral hippocampal entorhinal cortex and the right lateral basal almond were significantly lower than those in the normal control group (P <0.005). Conclusion: There are many abnormal brain tissue densities in occipital visual cortex and limbic system in children with school-age high functional dysfunction.