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成熟的Wistar雌性大鼠饲以不同剂量的炔雌醚和复方炔雌醚(炔雌醚与氯地孕酮配伍)。给药7个月后,用光镜和电镜观察子宫内膜和肝脏的形态结构变化。结果表明,长期给予大剂量炔雌醚可引起子宫内膜萎缩,而长期给予小剂量炔雌醚后,部分动物出现子宫内膜囊性增生过长,其他动物的内膜处于抑制状态,未见到腺瘤型和非典型性增生过长。另外,炔雌醚对肝细胞的光面内质网、线粒体和毛细胆管的影响,与文献中短效避孕药的影响相比均较轻微。
Mature Wistar female rats were fed different doses of ethinyl estradiol and compound ethynylestradiol (ethinylestradiol and chlormadinone compatibility). After 7 months of administration, morphological changes of endometrium and liver were observed with light microscope and electron microscope. The results showed that long-term high-dose ethinyl estradiol can cause endometrial atrophy, and long-term administration of a small dose of ethinyl estrone, some animals appear endometrial cystic hyperplasia too long, other animals intima in an inhibited state, no see To adenoma and atypical hyperplasia. In addition, the effects of ethinylestradiol on the smooth endoplasmic reticulum, mitochondria and capillary bile ducts of hepatocytes were mild compared with the short-acting contraceptives in the literature.