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目的 :探讨 CD4抗原在急性髓系白血病细胞上的表达及意义。方法 :对 82例急性髓系白血病患者进行免疫表型、细胞遗传学分析。结果 :CD4在 AML患者中表达率为 40 .2 % ,M5 中阳性率最高 92 .9% ,M4次之为5 5 % ,CD+4 AML 高表达 HL A- DR,CD3 8、CD3 3 、CD1 5 、CD1 4 、TB系列抗原阴性。CD+4 AML 中可见 11q2 3、inv(16 )、t(9;2 2 ) ,未见特异性染色体异常。但伴 11q2 3和 inv(16 )异常的 AML频繁表达 CD4,阳性率分别为 86 .3%、6 0 .2 %。CD+4和 CD- 4 AML 在年龄、性别、肝脾肿大、CNS- L、DIC、1疗程 CR率等临床特征方面无明显不同。结论 :CD+4 AML 是一组起源较早的具有单核细胞特征的髓系白血病 ,CD4的表达对 AML- M4、M5 尤其是 M5 亚型的鉴别诊断有重要价值
Objective: To investigate the expression and significance of CD4 antigen in acute myeloid leukemia cells. METHODS: Immunophenotype and cytogenetic analysis of 82 patients with acute myeloid leukemia were performed. Results: The expression rate of CD4 in patients with AML was 40.2%, the positive rate in M5 was 92.9%, and M4 was 55%. CD+4 AML was highly expressed in HL A-DR, CD3 8, CD3 3, The CD15, CD14, and TB series antigens are negative. 11q2 3, inv(16), t(9;2 2) were found in CD+4 AML, and no specific chromosomal abnormalities were found. However, AML with 11q2 3 and inv(16) abnormalities frequently expressed CD4, with a positive rate of 86.3% and 60.2%, respectively. CD+4 and CD-4 AML were not significantly different in terms of age, sex, hepatosplenomegaly, CNS-L, DIC, and 1-course CR rate. Conclusion :CD+4 AML is a group of myeloid leukemias with early monocyte characteristics. The expression of CD4 is of great value in differential diagnosis of AML-M4, M5 and especially M5 subtypes.