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Objective:To determine the seroprevalence of anti-Toxoplasma gondii(T. gondii) IgG and IgM antibodies inHIV/AIDS patients and uninfected subjects.Methods: This cross sectional survey was carried out on78 healthy and62 HIV+/AIDS individuals in north Iran between September 2007 and October2008. Five mL of blood samples were collected from each person in case and control groups. Determination ofCD4+ counts was performed by flow cytometry. The serum separated from blood samples was evaluated by conventionalELISA technique to determine the presence of antibodies toT. gondii.Results: Forty eight out of62 (77.4%) HIV/AIDS serum samples were found positive for anti-T. gondii IgG antibody, compared with59 among78 (75.6%) HIV negative samples from the same area (P>0.05). Six out of62 (9.7%) HIV+/AIDS patients showed anti-T. gondiiIgM antibody in their serum samples, compared with 7 among78 (9%) HIV negative samples(P>0.05). The mean ofCD4+ counts inHIV+/AIDS was(430.8±182.3)cells/μL and in control group was(871.0±243.3)% cells/μL (P<0.01).CD4+ estimation in5 (11.1%)ofHIV+/AIDS patients was<200 cells/μL (P<0.000 1).Conclusions: Seroprevalence of latent toxoplasmosis inHIV patients is high, therefore the prevention of toxoplasmic encephalitis, administration of primary prophylaxis with co-trimoxazole to allHIV+/AIDS patients are necessary.