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目的:观察5-氨基酮戊酸光动力疗法(ALA-PDT)或联合手术治疗鳞癌和Bowen病的临床疗效。方法:20例鳞癌,15例Bowen病行PDT治疗或PDT联合手术治疗。对于肿瘤表面有鳞屑结痂或高出皮面患者预先行削除和电灼。ALA配置成20%溶液涂于皮损;4~6 h后行波长635 nm红光照射,能量密度80~100 J/cm~2,时间20 min,每周照射1次,共3~6次。疗程结束后观察疗效并行病理检查,做出综合评价。结果:35例患者随访半年或1年均未见原肿瘤部位有
Objective: To observe the clinical efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) or combined surgery in the treatment of squamous cell carcinoma and Bowen’s disease. Methods: Twenty patients with squamous cell carcinoma and 15 patients with Bowen disease underwent PDT or PDT. On the surface of the tumor scab or scaly over the skin in patients with pre-removal and electrocautery. ALA was placed in 20% solution on the skin lesions; 4 ~ 6 h after the wavelength of 635 nm red light irradiation, the energy density of 80 ~ 100 J / cm ~ 2, time 20 min, weekly irradiation 1, a total of 3 to 6 times . Observed after the end of treatment efficacy of parallel pathological examination to make a comprehensive evaluation. Results: 35 patients were followed up for 6 months or 1 year did not see the original tumor site