论文部分内容阅读
目的:牛膝总皂苷对卒中型自发性高血压大鼠(SHRsp)卒中后血压、存活时间及平均寿命、神经症状、脑系数的影响。方法:将SHRsp大鼠随机分为牛膝总皂苷高、中、低剂量组(0.40,0.20,0.10 g.kg-1)、华佗再造丸组(2.5 g.kg-1)和模型组,正常组为SD大鼠,每组10只,连续给药20 d。观察牛膝总皂苷对SHRsp卒中后血压、神经状态变化、死亡率、脑系数及对海马区神经元的影响。结果:牛膝总皂苷可降低SHRsp大鼠血压,改善SHRsp脑卒中后的神经症状,延长卒中后存活时间,降低脑系数,降低脑卒中后大鼠死亡率,保护海马区神经元。结论:牛膝总皂苷对实验性SHRsp脑卒中有一定治疗作用。
Objective: To study the effects of total saponins of Achyranthes bidentata on the blood pressure, survival time, mean life span, neurological symptoms and cerebral coefficient after stroke in spontaneously hypertensive stroke rats (SHRsp). Methods: SHRsp rats were randomly divided into high, medium and low dose Achyranthes bidentata total saponins group (0.40,0.20,0.10 g.kg-1), Hua Tuozai pill group (2.5 g.kg-1) and model group, The normal group was SD rats, each group of 10, continuous administration of 20 d. To observe the effect of Achyranthes saponin on blood pressure, neurological status, mortality, cerebral coefficient and neurons in hippocampus after SHRsp stroke. Results: Achyranthes saponin could reduce the blood pressure of SHRsp rats, improve the neurological symptoms after SHRsp stroke, prolong the survival time after stroke, decrease the cerebral coefficient, reduce the rat mortality after stroke and protect the neurons in hippocampus. Conclusion: Achyranthes saponin has some therapeutic effect on experimental SHRsp stroke.