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目的:探讨毛细支气管炎发展为支气管哮喘的相关因素。方法:将长期随访的86例毛细支气管炎患儿纳入研究,采用χ2检验对哮喘发病率进行比较分析,采用多因素Logistic回归方法分析毛细支气管发展为哮喘的相关因素。结果:男性与女性患儿的哮喘发病率无统计学差异(P>0.01),有哮喘家族史、过敏体质患儿的哮喘发病率明显升高(P<0.01),接种卡介苗、使用免疫球蛋白、母乳喂养患儿的哮喘发病率明显较低(P<0.01)。结论:哮喘家族史、过敏体质是诱发支气管哮喘的危险因素,接种卡介苗、使用免疫球蛋白、母乳喂养是减少支气管哮喘发生的保护因素。
Objective: To investigate the related factors of the development of bronchiolitis to bronchial asthma. Methods: Totally 86 children with bronchiolitis were enrolled in the study. The incidence of asthma was analyzed by χ2 test. The factors related to the development of bronchial asthma were analyzed by multivariate Logistic regression. Results: There was no significant difference in the incidence of asthma between male and female children (P> 0.01). The incidence of asthma in children with family history of asthma and allergic constitution was significantly higher (P <0.01). BCG vaccination and immunoglobulin The incidence of asthma in breastfeeding children was significantly lower (P <0.01). Conclusion: The family history of asthma and allergy are the risk factors of bronchial asthma. Vaccination with BCG and immunoglobulin are the protective factors to reduce the incidence of bronchial asthma.