论文部分内容阅读
目的探索利用负载131I的骨水泥行经皮椎体成形术(PVP)治疗兔椎体肿瘤的安全性及有效性。方法将12只采用经皮穿刺接种法建立的兔VX2椎体肿瘤模型随机分成实验组和对照组,每组6只。实验组注射负载有放射性核素131I的骨水泥行PVP,对照组单纯注射骨水泥行PVP。两组实验动物于术前1 d、术后第4天检测血细胞计数,于PVP术前1 d及术后第1、4、8天行PET-CT检查,测定椎体肿瘤的核素标准化摄取值(SUV)。PVP后第1、4、8天对实验组动物行SPECT检查,了解131I在体内分布情况,在治疗后第8天取肿瘤椎体标本行病理检查。结果所有实验动物都顺利接受PVP治疗,实验组的放射性核素平均使用放射剂量为(0.82±0.14)mCi/kg。两组实验动物PVP前、后血细胞计数结果差异无统计学意义。PVP后SPECT检查见131I主要聚集在病变椎体内,术后各时间点内其分布无明显变化。两组动物术前SUV值差异无统计学意义(F=0.765,P>0.05),实验组动物PVP后椎体肿瘤的SUV值较术前明显降低,且数值稳定(F=423.792,P<0.05)。病理检查结果显示实验组骨水泥周边肿瘤细胞坏死范围明显大于对照组。结论采用负载131I的骨水泥行PVP治疗椎体肿瘤,方法可行,短期内随访结果安全、有效。
Objective To explore the safety and efficacy of percutaneous vertebroplasty (PVP) using 131I-loaded cement in the treatment of vertebral body tumors in rabbits. Methods Twelve rabbit models of VX2 vertebral tumor established by percutaneous inoculation were randomly divided into experimental group and control group, with 6 in each group. The experimental group was injected with PVP loaded with radionuclide 131I and the control group with PVP injected with cement alone. Blood samples were collected on the first day before operation and on the fourth day after operation in both groups. PET-CT was performed on the first day before PVP and the first, the fourth and the eighth day after PVP. The radionuclide normalized uptake Value (SUV). SPECT was performed on the experimental animals on the 1st, 4th and 8th day after PVP to understand the distribution of 131I in vivo. The tumor specimens were taken for pathological examination on the 8th day after treatment. Results All the experimental animals received PVP successfully. The mean radionuclide dosage of the experimental group was (0.82 ± 0.14) mCi / kg. There was no significant difference in blood cell count before and after PVP between two groups of experimental animals. After PVP SPECT examination showed 131I mainly concentrated in the lesion vertebral body, postoperative no significant change in its distribution at any time point. There was no significant difference in the preoperative SUV between the two groups (F = 0.765, P> 0.05). The SUV of the vertebral body tumor in the experimental group was significantly lower than that before the operation (F = 423.792, P <0.05) ). Pathological examination showed that the experimental group of peripheral bone tumor necrosis area was significantly larger than the control group. Conclusion The application of 131I-loaded bone cement in the treatment of vertebral body tumors is feasible and safe and effective in short-term follow-up.