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目的探讨多发性骨髓瘤患者早期死亡的临床危险因素。方法回顾性分析18例早期死亡(6个月内)的初治多发性骨髓瘤患者的临床资料。单因素和LOGISTIC回归多因素分析影响多发性骨髓瘤患者早期死亡的临床危险因素。结果单因素分析发现,年龄、血乳酸脱氢酶(LDH)水平、血白蛋白水平、血肌酐(CR)水平、血Β2微球蛋白(Β2“MG)水平和是否合并有淀粉样变是早期死亡的危险因素;而多因素分析确定只有血白蛋白水平、血CR水平、血Β2”MG水平及是否合并有淀粉样变是早期死亡的危险因素。结论低白蛋白血症、肾功能不全、高血Β2“MG水平、合并有淀粉样变的多发性骨髓瘤患者是早期死亡的高危患者。
Objective To investigate the clinical risk factors of early death in patients with multiple myeloma. Methods The clinical data of 18 patients with early-stage multiple myeloma who died early (within 6 months) were retrospectively analyzed. Logistic regression and logistic regression multivariate analysis of clinical risk factors affecting early death in patients with multiple myeloma. Results Univariate analysis showed that age, serum LDH level, serum albumin level, serum creatinine (CR) level, blood B2 microglobulin (Β2 ”MG) level and amyloidosis were Risk factors for early death; and multivariate analysis identified only the level of serum albumin, blood CR levels, blood levels of Β2 "MG and whether amyloidosis is a risk factor for early death. Conclusions Hypoalbuminemia, renal insufficiency, and high blood glucose levels in patients with multiple myeloma with amyloidosis are high risk patients with early death.