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目的探讨急性有机磷农药中毒(AOPP)患者尿微量白蛋白水平的变化及意义。方法用速率散射比浊法检测71例AOPP患者尿微量白蛋白含量,并与正常对照组(45例)比较。结果71例AOPP患者中,20例中毒后尿微量白蛋白水平逐渐增高,且随着病情的发展尿蛋白呈阳性;51例尿蛋白阴性患者尿微量白蛋白含量增高16例,在中毒后第1、3、5天,其尿微量白蛋白含量中位数分别为2.12、2.31、1.70g/molCr,均高于正常对照组(1.25g/molCr),差异有统计学意义(P<0.05),且中毒愈重,尿微量白蛋白增高愈明显。结论尿微量白蛋白对AOPP患者肾损害的早期诊断有参考价值。
Objective To investigate the changes and significance of urinary albumin in patients with acute organophosphorus pesticide poisoning (AOPP). Methods The urine microalbuminuria in 71 patients with AOPP was detected by rate nephelometry and compared with that of the normal control group (45 cases). Results In 71 AOPP patients, urine microalbumin levels gradually increased after 20 cases of poisoning, and urinary protein was positive with the progression of disease. Urinary albumin in 51 cases with urinary protein-negative patients increased in 16 cases, , 3,5 days. The median urinary albumin contents were 2.12, 2.31 and 1.70 g / molCr, respectively, which were significantly higher than those of the normal control group (1.25 g / molCr) (P <0.05) And the more poisoning, urinary albumin increased more obvious. Conclusion Urine microalbumin has a reference value for the early diagnosis of renal damage in patients with AOPP.