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目的探讨CA125联合CA199检测在子宫内膜异位(EMs)诊断中的价值及临床意义。方法以2013年3月至2014年2月收治的EMs患者48例、卵巢上皮癌(EOC)患者44例、卵巢良性肿瘤(BOT)36例为研究对象,检测其血清CA125和CA199水平。结果 Ems患者血清CA125、CA199水平明显高于BOT患者(均P<0.05),而低于EOC患者(均P<0.05)。血清CA125、CA199从BOT组、Ems组到EOC组均呈明显增加趋势,且两者呈正相关(r=0.7587,P<0.05)。血清CA125和CA199联合检测对Ems、EOC的诊断灵敏度明显高于单项检测(均P<0.05),但特异度、准确度较单项指标略有下降。结论 CA125联合CA199可提高Ems诊断灵敏度,但特异度低,可作为Ems的辅助诊断指标。
Objective To investigate the value of CA125 combined with CA199 in the diagnosis of endometriosis (EMs) and its clinical significance. Methods 48 patients with EMs, 44 patients with epithelial ovarian cancer (EOC) and 36 patients with benign ovarian tumors (BOT) were enrolled in this study from March 2013 to February 2014. The serum levels of CA125 and CA199 were measured. Results The levels of serum CA125 and CA199 in Ems patients were significantly higher than those in BOT patients (all P <0.05), but lower than those in EOC patients (all P <0.05). Serum CA125 and CA199 showed a trend of increasing from BOT group, Ems group to EOC group, and there was a positive correlation between them (r = 0.7587, P <0.05). The diagnostic sensitivity of combined detection of serum CA125 and CA199 to Ems and EOC was significantly higher than that of single detection (all P <0.05), but the specificity and accuracy were slightly lower than those of single index. Conclusion CA125 combined with CA199 can improve the diagnostic sensitivity of Ems, but the specificity is low and can be used as an auxiliary diagnostic indicator of Ems.