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作者报道6例单纯红细胞再生障碍性贫血(PRCA),原先5例对常规免疫抑制治疗无效,1例忌用糖皮质激素。4例病程≥11年。2例系先天性。启用环孢素A(CsA)治疗,初量为5-10mg/公斤体重/日,每日分两次服。例1初量为15mg/kg/日。每周按2mg/kg/日增量,直至血液学改善或出现肾毒性反应(血清肌酐值增加30%)。单用Cs 2例与强的松龙联用4例(其中2例生效后停用强的松龙),疗程9 46个月(中数27个月)。5例取得血液学完全缓解(CR),1例部分缓解(PR)。6例治疗前血红蛋白(Hb)值64±13g/L(41-80g/L),Cs治疗后6个月Hb值104±17g/L(80-125g/L)有显著性改善(P<0.005)。半数患者有剂量依赖性,需以Cs维持
The authors report 6 cases of pure red cell aplasia (PRCA), the original 5 cases of conventional immunosuppressive therapy is invalid, 1 case of detoxification with glucocorticoid. 4 cases duration ≥ 11 years. 2 cases of congenital. Enable cyclosporin A (CsA) treatment, the initial amount of 5-10mg / kg body weight / day, twice daily service. Example 1 initial amount of 15mg / kg / day. Weekly 2mg / kg / day increments until hematologic improvement or nephrotoxicity (serum creatinine value increased by 30%). In 2 cases of Cs alone, 4 cases were treated with prednisolone (2 of them stopped using prednisolone after taking effect), and the course of treatment was 946 months (median 27 months). Five patients achieved hematologic complete remission (CR) and one patient had partial remission (PR). Hb value of 64 ± 13g / L (41-80g / L), Hb value of 104 ± 17g / L (80-125g / L) ). Half of the patients were dose-dependent and required Cs maintenance