论文部分内容阅读
目的了解肇庆市1~59岁人群乙型肝炎病毒表面抗原(HBsAg)携带率和乙型肝炎病毒感染率,为制订预防控制策略提供依据。方法抽取678人进行血清流行病学调查,用固相放射免疫法、酶联免疫吸附试验(ELISA)夹心法进行相应项目检测。结果678份血清中HBsAg阳性率为10.77%;HBsAb阳性率为64.75%;HBeAg阳性率为3.54%;HBeAb阳性率为7.23%;HBcAb阳性率为33.78%;男、女性人群HBsAg阳性率分别为11.55%、10.03%,城、乡人群HBsAg阳性率分别为7.12%,14.37%;在HBsAg阳性人群中,HbeAg、抗-HBe标化阳性率分别为32.88%和67.12%;而HBsAb阳性人群中,单HBsAb阳性的占68.34%,HBsAb和HBcAb都阳性的占31.66%,单HBcAb阳性的占3.87%;小于15岁与大于15岁人群HBsAg阳性率、HBV感染率差异均有统计学意义。结论肇庆市HBsAg阳性率与全国平均水平相近,而流行率则低于全国平均水平;肇庆市乙肝疫苗纳入计划免疫管理10余年,15岁以下儿童HBV感染率已大幅度下降。
Objective To understand the prevalence of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus (HBV) infection in 1-59-year-olds in Zhaoqing City, and to provide evidence for the development of prevention and control strategies. Methods Six hundred and seventy-eight people were enrolled for serological epidemiological investigation, and the corresponding items were detected by solid phase radioimmunoassay and enzyme-linked immunosorbent assay (ELISA) sandwich method. Results The positive rate of HBsAg in 678 serums was 10.77%, the positive rate of HBsAb was 64.75%, the positive rate of HBeAg was 3.54%, the positive rate of HBeAb was 7.23%, the positive rate of HBcAb was 33.78%, and the positive rate of HBsAg in male and female was 11.55 %, 10.03%. The positive rates of HBsAg in urban and rural areas were 7.12% and 14.37%, respectively. The positive rates of HbeAg and anti-HBe in HBsAg positive population were 32.88% and 67.12% respectively, while in HBsAb positive population HBsAb positive accounted for 68.34%, HBsAb and HBcAb positive accounted for 31.66%, single HBcAb positive accounted for 3.87%; less than 15 years old and over 15 years old HBsAg positive rate, HBV infection rate differences were statistically significant. Conclusions The positive rate of HBsAg in Zhaoqing is similar to the national average, but the prevalence is lower than the national average. Hepatitis B vaccine in Zhaoqing is included in the planned immunization management for more than 10 years, and the HBV infection rate in children under 15 years of age has dropped significantly.