干燥性角膜结膜炎(Keratoconjunctivitis sicca,KCS)是原发于泪腺分泌减退所引起的常见眼病。自1933年瑞典眼科医生Sjgren报告口眼干燥关节炎综合征以来,文献上将本病归人该综合征的范围,通称Sjg ren综合征(SS)。实际上SS在临床上应包括两种类型,狭义的SS是指单纯的KCS和口腔干燥症而言,一般称为单纯型SS;广义的SS是指除口眼干燥外,还合并有类风湿关节炎(RA)或其它自家免疫性疾病,故称为重叠型SS。关于后者无论是从发病率还是从预后和发病机理的探讨,都是SS的重点,近来文献已有较多的报告。本文仅从眼科的角度出发,重点对KCS的检查、诊断和治疗等几个方面的最近看法进行综述。 Keratoconjunctivitis sicca (KCS) is a common ocular disease caused by decreased secretion of the lacrimal gland. Since the 1933 Swedish ophthalmologist Sjögren reported oral dry arthritis syndrome, the literature will be classified as the disease within the scope of the syndrome, commonly known as Sjögren’s syndrome (SS). In fact SS should include two types of clinical, narrow sense of SS refers to the simple KCS and xerostomia, generally referred to as simple SS; generalized SS refers to the dry mouth, but also combined with rheumatoid Arthritis (RA) or other autoimmune diseases, it is called overlapping SS. About the latter, whether from the incidence or from the prognosis and pathogenesis of the discussion, are the focus of SS, the recent literature has been more reported. This article only from the perspective of ophthalmology, focusing on KCS examination, diagnosis and treatment of several recent views are reviewed.