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随着异种移植理论的发展 ,逐渐认识到转基因动物的修饰应主要针对其血管内皮细胞组织 ,并在建立转基因动物中构建特异的转录调控元件 ,获得补体调节蛋白在转基因动物血管内皮细胞组织特异性高效表达。本文就近几年有关异种移植领域转基因动物补体调节蛋白高效特异性表达方面研究进展作一综述
With the development of xenotransplantation theory, it is gradually realized that the modification of transgenic animals should mainly target the vascular endothelial cells and construct the specific transcriptional regulatory elements in the transgenic animals, so as to obtain the complement specificity of complement regulatory proteins in the vascular endothelial cells of transgenic animals Efficient expression. This review summarizes recent progress in the study of the efficient and specific expression of complement regulatory proteins in transgenic animals in the field of xenotransplantation