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目的:测定各型活动性幼年特发性关节炎(JIA)患儿血清中IL-1、IL-10、TNF-α水平,探讨其与疾病活动、疾病分型以及疾病严重程度的关系。方法:用放射免疫法(RIA)检测IL-1、IL-10、TNF-α水平。结果:30例JIA患者血清中IL-1、TNF-α水平明显高于健康对照组(P<0.001或P<0.01);并与血沉(ESR)、C-反应蛋白(CRP)呈正相关(P<0.001);而与关节肿胀指数、夜间痛及X线分级无关。30例JIA患者血清中IL-10与健康对照组之间相比无统计学意义,并与上述所有观察指标无相关关系。结论:JIA患者血清中IL-1、TNF-α水平显著升高,可能参与了JIA的发病过程,可与ESR、CRP一起作为判断病情活动性的指标,但与疾病严重程度无关,与JIA分型无关。IL-10可能是一种抑炎因子,有抑制关节骨质破坏的作用,针对IL-10的基因及受体治疗可作为控制关节炎症的保护性手段。
Objective: To determine the levels of IL-1, IL-10 and TNF-α in sera of children with idiopathic juvenile idiopathic arthritis (JIA), and to explore their relationship with disease activity, disease type and disease severity. Methods: The levels of IL-1, IL-10 and TNF-α were detected by radioimmunoassay (RIA). Results: Serum levels of IL-1 and TNF-α in 30 JIA patients were significantly higher than those in healthy controls (P <0.001 or P <0.01), and were positively correlated with ESR and CRP <0.001), but not related to joint swelling index, nocturnal pain and X-ray classification. There was no significant difference between serum IL-10 and healthy controls in 30 JIA patients, and there was no correlation between IL-10 and all above-mentioned indexes. Conclusion: The levels of IL-1 and TNF-α in serum of patients with JIA are significantly increased, which may be involved in the pathogenesis of JIA. ESR and CRP may be used as indicators to determine the activity of JIA patients, but not with the severity of JIA Has nothing to do with type. IL-10 may be an anti-inflammatory factor that inhibits the destruction of joint bone. The treatment of IL-10 gene and its receptors may be used as a protective measure against arthritis.