随着T细胞受体(TcR)的深入研究,Moingeon等发现几株表达TorY的克隆可介导非MHC约束性的杀瘤作用,进而提出了T细胞受体γ基因编码一种NK细胞抗原受体分子的假设。为此,作者检测了三株不同表型的NK克隆及两例CD_16~+淋巴细胞增多症患者的具有NK活性的PBL中的TcRα、β、γ基因的重排和表达。进一步证实了某些NK With the further study of T cell receptor (TcR), Moingeon et al. Found that several TorY-expressing clones can mediate non-MHC binding tumorigenicity, and then proposed that the T cell receptor gamma gene encodes a NK cell antigen Body of hypotheses. To do this, we examined the rearrangement and expression of the TcRα, β, and γ genes in PBLs with NK activity in three NK phenotypes and two patients with CD16 + lymphocytosis. Further confirmed that some NK