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目的探讨胺碘酮对心律失常患者血清超敏C-反应蛋白(hs-CRP)水平及心率变异性的影响。方法选取心律失常患者76例,按随机数表法分为对照组与观察组,每组38例。对照组采用普罗帕酮治疗,观察组采用胺碘酮治疗,比较两组患者血清hs-CRP水平及心率变异性。结果治疗前,两组患者24 h内每5 min正常RR间期标准差的平均值(SDNN index)、RR间期平均值标准差(SDANN)、相邻RR间期差值的均方根(r MSSD)、全部窦性心搏RR间期标准差(SDNN)指标及血清hs-CRP水平比较,差异未见统计学意义(P>0.05);治疗4周后,观察组血清hs-CRP水平较对照组降低,SDNN index、SDANN、rMSSD、SDNN指标升高,差异有统计学意义(P<0.05)。结论胺碘酮可有效降低心律失常患者血清hs-CRP水平,改善患者心率变异性。
Objective To investigate the effect of amiodarone on serum hs-CRP and heart rate variability in patients with arrhythmia. Methods Totally 76 patients with arrhythmia were divided into control group and observation group according to random number table method, with 38 cases in each group. The control group was treated with propafenone. The observation group was treated with amiodarone. The serum hs-CRP levels and heart rate variability were compared between the two groups. Results Before treatment, SDNN index, standard deviation of mean RR interval (SDANN), root mean square (RMS) of RR interval difference r MSSD), SDNN and serum hs-CRP levels in all sinus beats (P> 0.05). After 4 weeks of treatment, the level of serum hs-CRP in the observation group was significantly higher than that of the control Group decreased, and SDNN index, SDANN, rMSSD, SDNN index increased, the difference was statistically significant (P <0.05). Conclusions Amiodarone can effectively reduce the level of serum hs-CRP in patients with arrhythmia and improve the heart rate variability.