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为估计抗精神病药恶性综合征（ＮＭＳ）的发生率，探讨ＮＭＳ发生的原因、临床特征、治疗及预后情况，采用回顾性临床分析方法并根据Ｐｏｐｅ等及Ｌｅｖｅｎｓｏｎ等提出的ＮＭＳ的诊断标准进行确定诊断。结果显示，在我院１９８０～１９９３期间３１７４６例用抗精神病药的住院病人有４０例发生ＮＭＳ，发生率为０．１３％，其中男２８例（７０．０％），女１２例（３０．０％），平均年龄为３２．０±１０．４岁。平均用药剂量为９８４±６２１ｍｇ／日（折合氯丙嗪剂量），合并用药３１例（７７．５％），单一用药９例（２２．５％）。合并用药组使用长效制剂２２例（７１．０％），氟哌啶醇１２例（３９．０％）。单一用药组使用氟哌啶醇５例。共死亡８例，死亡率为２０．０％。这提示ＮＭＳ发生率明显低于所知的国外报道。本征多见于青年男性，尤其是合并用药、使用氟哌啶醇及长效制剂更易发生ＮＭＳ。个体因素也是发生ＮＭＳ的危险因素之一。早期发现和早期治疗有益于本综合征的预后
To assess the incidence of antipsychotic malignant syndrome (NMS) and to investigate the causes, clinical characteristics, treatment and prognosis of NMS, a retrospective clinical analysis was performed and based on the diagnostic criteria of NMS proposed by Pope et al. And Levenson et al. diagnosis. The results showed that in our hospital from 1980 to 1993 31,746 cases of antipsychotic inpatients with NMS occurred in 40 cases, the incidence was 0.13%, of which 28 males (70.0%) and 12 females (30. 0%), with an average age of 32.0 ± 10.4 years. The average dosage was 984 ± 621mg / day (equivalent to chlorpromazine dose), 31 cases (77.5%) were combined and 9 cases (22.5%) were single drug. Long-acting preparations were used in combination group, 22 cases (71.0%) and haloperidol (12 cases, 39.0%). A single drug group use haloperidol in 5 cases. A total of 8 deaths, the mortality rate was 20.0%. This suggests that the incidence of NMS is significantly lower than the known foreign reports. More common in young men, especially the combination of medication, the use of haloperidol and long-acting agents more prone to NMS. Individual factors are also one of the risk factors for developing NMS. Early detection and early treatment benefit the prognosis of this syndrome