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为探讨血清神经元特异性烯醇酶（NSE）、血浆内皮素-1（ET－1）与新生儿缺氧缺血性脑病（HIE）的关系，分别用酶联免疫法和放射免疫法测定25例正常足月新生儿和59例足月HIE新生儿血清中NSE浓度和血浆ET-1浓度，并观察其动态变化（生后24小时内、第3天、第7天）。结果HIE中、重度组生后3天内NSE显著高于对照组和轻度组（P＜0.01）；第7天逐渐下降，但重度组仍高于轻、中度组和对照组（P＜0．01）。ET－1浓度于生后3天内HIE组显著高于对照组，且重度组高于中度组，中度组高于轻度组（P均＜0．01）；第7天逐渐下降，但中、重度组仍高于对照组和轻度组（P＜0.01）。24小时内和第3天NSE与ET－1浓度呈正相关（P＜0．01）。NSE、ET－1浓度在生后3天内升高和在第七天持续不降者预后不良。提示NSE与ET-1浓度改变可作为新生儿HIE脑损伤的早期生化指标，为早期干预提供机会和理论依据。
To investigate the relationship between serum neuron specific enolase (NSE), plasma endothelin-1 (ET-1) and neonatal hypoxic ischemic encephalopathy (HIE), the levels of serum neuron specific enolase (NSE) and radioimmunoassay The serum concentrations of NSE and plasma ET-1 in 25 normal newborn infants and 59 full-term neonates with HIE were observed. The changes of NSE and plasma ET-1 concentrations were observed and the changes were observed (within 24 hours after birth, on day 3 and day 7). Results The levels of NSE in HIE group were significantly higher than those in control group and mild group (P <0.01), and gradually decreased on the 7th day in HIE group, but still higher in severe group than in mild and moderate group .01). The concentration of ET-1 in HIE group was significantly higher than that in control group within 3 days after birth, and the severe group was higher than the moderate group, the moderate group was higher than the mild group (P <0.01), and gradually decreased on the 7th day Moderate and severe group is still higher than the control group and mild group (P <0.01). There was a positive correlation between NSE and ET-1 concentration within 24 hours and on the 3rd day (P <0.01). NSE, ET-1 levels increased within 3 days after birth and continued to decline on the seventh day were associated with poor prognosis. These results suggest that the changes of NSE and ET-1 levels may be used as early biochemical markers of brain injury in neonates with HIE, providing opportunities and theoretical basis for early intervention.