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[目的]观察大黄利胆胶囊联合吗啡控释片治疗中重度癌性疼痛疗效。[方法]使用随机平行对照方法,将52例住院及门诊患者按随机数字表法随机分为两组。对照组26例口服吗啡缓释片,30mg/粒,90mg/次,3次/d。治疗组26例大黄利胆胶囊,0.8mg/粒,2.1mg/次,3次/d,睡前口服。西药治疗同对照组。连续治疗7d为1疗程。观测临床症状、药物副作用。连续治疗1疗程,判定疗效。[结果]治疗组显效18例,有效5例,无效3例,总有效率88.45%;对照组显效15例,有效7例,无效4例,总有效率84.61%。临床疗效两组间无明显差异(P>0.05)。药物副作用治疗组明显低于对照组(P<0.05)。[结论]大黄利胆胶囊联合吗啡控释片治疗中重度癌性疼痛疗效可靠,降低药物副作用发生率,值得推广。
[Objective] To observe the curative effect of rhubarb-li-chuan capsule combined with morphine controlled-release tablets in the treatment of moderate-severe cancer pain. [Methods] Using randomized parallel method, 52 inpatients and outpatients were randomly divided into two groups according to random number table method. Control group, 26 cases of oral morphine sustained-release tablets, 30mg / tablets, 90mg / times, 3 times / d. The treatment group, 26 cases of rhubarb, gallbladder capsules, 0.8mg / tablets, 2.1mg / time, 3 times / d, orally before going to bed. Western medicine treatment with the control group. Continuous treatment 7d for a course of treatment. Observation of clinical symptoms, drug side effects. Continuous treatment of a course of treatment to determine the efficacy. [Result] In the treatment group, 18 cases were markedly effective, 5 cases were effective, 3 cases were ineffective and the total effective rate was 88.45%. In the control group, 15 cases were markedly effective, 7 cases were effective and 4 cases were ineffective. The total effective rate was 84.61%. Clinical efficacy no significant difference between the two groups (P> 0.05). Side effects of the drug treatment group was significantly lower than the control group (P <0.05). [Conclusion] Rhubarb, Lactobacillus combined with Morphine controlled release tablets in the treatment of moderate and severe cancerous pain is reliable, reducing the incidence of side effects of drugs, which is worth promoting.