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目的探讨基本消除丝虫病后残存微丝蚴血症者在不采取任何病原防治措施下的传播作用。方法选择柘城县张庄村为观察点,病原学监测和蚊媒监测采取常规方法,血清学检测采用IFAT、ELISA、Dot-ELISA(查抗体)和ICT(查循环抗原)方法,同时进行居民防蚊情况调查。结果1990年残存微丝蚴血症者39人,人群微丝蚴率2.01%(39/2040),2000年微丝蚴血症者全部转阴,人群微丝蚴率降为0;1990、1991和1994年检测人群丝虫抗体阳性率和抗体阳性者的几何平均滴度均逐渐下降,1998年检测92名12岁以下儿童血中丝虫循环抗原均为阴性;淡色库蚊幼丝虫自然感染率逐年下降,自1997年未再发现感染蚊;1990~2002年当地居民经济收人逐渐增加,普遍采取防蚊措施。结论基本消除丝虫病后,随居民经济和文化水平的逐渐提高,防病意识的不断增强以及防蚊措施的加强,即使未采取任何干预措施,残存微丝蚴血症者也不能引发丝虫病流行,丝虫病传播已经被阻断。
Objective To explore the basic elimination of microfilaremia microfilaria after filariasis in the absence of any pathogen prevention and control measures under the transmission. Methods The Zhangzhuang village of Tancheng County was selected as the observation point. The etiological and mosquito vectors were monitored by routine methods. Serological tests were carried out by IFAT, ELISA, Dot-ELISA (Antibody Detection) and ICT (Circulating Antigen Check) Investigation of mosquitoes Results In 1990, 39 patients with microfilaremia were observed, the crowd microfilaria rate was 2.01% (39/2040). In 2000, microfilariae were all negative and microfilariae rate was reduced to 0 in 1990,1991 And the average prevalence of filamentous worm antibody and the average geometric mean antibody titer of the test population in 1994 were all gradually decreased. In 1998, 92 blood samples from children under 12 years of age were negative for filarial circulating antigens; The rate of decline year by year since 1997, no further detection of mosquitoes; 1990-2002 local residents economic income gradually increased, the general anti-mosquito measures. Conclusion After the basic elimination of filariasis, with the gradual increase of economic and cultural level of inhabitants, the increasing awareness of disease prevention and the strengthening of anti-mosquito measures, even those who did not take any interventions could not induce filarial worms Epidemics, transmission of filariasis have been blocked.