我院从1988年到1994年随访观察了105例房间隔缺损患儿,其中单纯继发孔型82例,原发孔型21例,多孔型、先天愚型并继发孔房间隔缺损各1例。单纯继发孔型房间隔缺损82例患儿中,有7例自然闭合;<2岁34例,闭合6例,闭合率为17.6％;2～5岁32例,闭合1例,闭合率为3.1％,>5岁者未见闭合。原发孔型房间隔缺损,症状体征明显,无自然闭合者,多孔型、先天愚型并继发孔型房间隔缺损者,亦无自然闭合。本文提示:单纯继发孔型房间隔缺损患儿,若年龄<5岁,症状轻,缺损≤0.7cm,QP:QS<2:1,有自然闭合的可能,可定期随访。 Our hospital from 1988 to 1994 were followed up 105 cases of atrial septal defect in children, including simple secondary to 82 cases of primary, primary hole in 21 cases, porous, Down’s syndrome and secondary atrial septal defect 1 example. Of the 82 cases of simple secondary atrial septal defect, 7 cases were closed naturally; 34 cases were <2 years old and 6 cases closed, the closing rate was 17.6%; 32 cases were 2 to 5 years old, 1 case closed, the closing rate was 3.1%,> 5 ​​years old have not closed. Primary atrial septal defect, obvious symptoms and signs, no natural closure, porous, Down’s syndrome and secondary orifice atrial septal defect, there is no natural closure. This article suggests that: children with simple secondary atrial septal defect, if the age <5 years old, mild symptoms, defects ≤ 0.7cm, QP: QS <2: 1, the natural closure may be regular follow-up.