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本文记述了用鼠疫强毒菌512号菌株感染鼠疫疫区旱獭的试验,初次感染时。10亿个菌组的旱獭全部死亡。感染一年后,对存活的旱獭再次攻击则可耐受700亿菌,其耐受性明显增加。旱獭感染后的嗜中性白细胞数量高于感染前,10天后恢复正常。旱獭初次感染鼠疫后,5天内不产生抗体,10天后阳性率为100％,最高滴度为1:1280。再次感染5天后的阳性率达100％,最高滴度为1:40960,可持续一年之久(1:40)。初次和再次感染之旱獭血清,其MPI分别为<10和<5,E-玫瑰花结合力和淋巴细胞转化率显著高于感染后(p<0.05)。 本研究有助于青海喜马拉雅旱獭动物流行病的调查。
This article describes the use of virulent Staphylococcus plague No. 512 strains of plague infected platypus test, initial infection. Marmots of 1 billion bacteria groups all died. After one year of infection, the survival of the marmot re-attack can tolerate 70 billion bacteria, its tolerance increased significantly. The number of neutrophils infected by Marmots was higher than that before infection and returned to normal after 10 days. After the first plague infection, the mites did not produce antibodies within 5 days and the positive rate was 100% after 10 days with the highest titer of 1: 1280. After 5 days of infection again the positive rate of 100%, the highest titer of 1: 40960, sustainable one year (1:40). In the first and re-infected marmot serum, MPI was <10 and <5, respectively, and E-rosette binding and lymphocyte transformation rates were significantly higher than those after infection (p <0.05). This study is helpful to investigate the animal epidemics of the Himalayan marmot in Qinghai Province.